Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the trpm2 channel in hippocampal neurons

HIGHLIGHTS

• who: Xin Li from the (UNIVERSITY) have published the Article: Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons, in the Journal: (JOURNAL)
• what: The authors aimed to elucidate the mechanisms for Aβ42-induced TRPM2 channel Official journal of the Cell Death Differentiation Association activation, alteration in intracellular Zn2+ homeostasis and neurotoxicity in hippocampal neurons. This study reveals multiple mechanisms that form a positive feedback loop to drive Aβ42-induced TRPM2-dependent hippocampal neurotoxicity (Fig 10). The authors provide . . .
  

   

  

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