Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model

HIGHLIGHTS

• who: Kunitaka Yoshida from the In this study, we have demonstrated that an adenovirus-prime/emBDES-boost regimen induces hybrid immune responses consisting of humoral and cellular responses to PfCSP, and affords high sterile protection against sporozoite challenge via two different routes, infectious mosquito bites (77% protection) and the iv. injection of sporozoites (62.5% protection), under different conditions at various institutes, including Kanazawa University, Imperial College London, and the Jenner Institute. In many experiments, challenge with i.v. injection has been preferentially used in a range of institutes because the sporozoite dose can be predetermined, even . . .
  

   

  

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