HIGHLIGHTS
- who: Frederic Daste et al. from the Department University of Cambridge, Cambridge, England, UK have published the research: Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature, in the Journal: (JOURNAL) of 14/09/2022
- what: The authors show that the SNX9-driven actin comets that arise on human disease-associated oculocerebrorenal syndrome of Lowe (OCRL) deficiencies are reduced by inhibiting PI(3)P production suggesting PI(3)P kinase inhibitors as a therapeutic strategy in Lo the authors syndrome. Rather than PI(3,4)P2 being a direct agonist of . . .
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