Co-operative and hierarchical binding of c-flip and caspase-8: a unified model defines how c-flip isoforms differentially control cell fate

HIGHLIGHTS

• who: Michelle A. Hughes from the Toxicology Unit, Hodgkin Building, POBox, Lancaster Road, Leicester , HN, UKUniversity of have published the article: Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate, in the Journal: (JOURNAL) of March/17,/2016
• what: Using a functional reconstituted DISC structure-guided mutagenesis and quantitative LC-MS/MS the authors show that c-FLIPL/S binding to the DISC instead a co-operative procaspase8-dependent process. Using quantitative mass spectrometry and confocal imaging, the authors show that . . .
  

   

  

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