Mmu-mir-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the bgn-mediated bmp/smad pathway

HIGHLIGHTS

• who: Qi Cui from the Mmu-miR-185-KO)mice were generated by the Shanghai Model Organisms Center (China) using CRISPR/Cas, technologyGenotyping was performed using DNAs extracted from mice tails, and KO mice were identified with a loss of , bp in genomes, which covers the whole precursor-mi, encoding sequence. All mice used in the study were housed and bred in the Department of Laboratory Animal Science, Peking University Health Sciences Center (Beijing, China). Mice used had free access to clean water and food, and were maintained under a , h light/dark cycle. All animal experiments . . .
  

   

  

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