Tuning liposome membrane permeability by competitive peptide dimerization and partitioning-folding interactions regulated by proteolytic activity

HIGHLIGHTS

  • who: Seng Koon Lim from the CentreUniversity, Research Techno Plaza, th storey XFrontiers block, Nanyang Drive, Singapore, have published the paper: Tuning Liposome Membrane Permeability by Competitive Peptide Dimerization and Partitioning-Folding Interactions Regulated by Proteolytic Activity, in the Journal: Scientific Reports Scientific Reports
  • what: The authors exploited the recognition of head group modified lipids to boost and tune the membrane disrupting effect of a de novo designed AMP-like helix-loop-helix peptide (JR2KC). The authors show the possibilities to tune the activity of this membrane active peptide by a specific and competitive folding . . .

     

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