Influences of the n700s thrombospondin-1 polymorphism on protein structure and stability*

HIGHLIGHTS

• who: C. Britt Carlson from the CBritt Carlson1, Yuanyuan Liu, James L. Keck, and Deane F. Mosher, From the Departments of Medicine and Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin , Thrombospondins (THBSs) are multimodular, secreted proteins characterized by a signature domain comprising a unique set of , calcium-binding repeats flanked by epidermal growth factor (EGF)-like and lectin-like modules. A polymorphism that changes a conserved Asn to Ser at residue , in the most, terminal calcium-binding repeat of , (repeat C) is found in , % of European populations and has been linked to increased risk of premature coronary . . .
  

   

  

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