Bacteriophage-mediated glucosylation can modify lipopolysaccharide o-antigens synthesized by an atp-binding cassette (abc) transporter-dependent assembly mechanism*

HIGHLIGHTS

• who: Evan Mann from the Evan Mann1, Olga GOvchinnikova1, Jerry D. King, and Chris Whitfield, From the Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N G , Canada Background: Bacteriophage-mediated seroconversion by glucosylation is currently unknown for, antigens synthesized by ABC transporter-dependent pathways. Results: Raoultella terrigena, antigen is modified with a glucose side chain when expressed in E. coli, . Conclusions: The ABC transporter-dependent pathway poses no intrinsic mechanistic barrier to phage-mediated glucosylation. Significance:, antigen glucosylation has implications for evolution of antigenic diversity and vaccine development. Lysogenic bacteriophages may encode enzymes . . .
  

   

  

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