Calphostin-c induction of vascular smooth muscle cell apoptosis proceeds through phospholipase d and microtubule inhibition*

HIGHLIGHTS

• who: Xi-Long Zheng from the (UNIVERSITY) have published the research work: Calphostin-C Induction of Vascular Smooth Muscle Cell Apoptosis Proceeds through Phospholipase D and Microtubule Inhibition*, in the Journal: (JOURNAL) of September/29,/2003
• what: The authors show here that apoptosis is inhibited by the addition of exogenous phosphatidic acid, a metabolite of phospholipase D (PLD), and that calphostin-C inhibits completely the activities of both isoforms of PLD, PLD1 and PLD2. In this report, the authors show that calphostin-C induces apoptosis of VSMCs through its inhibition of PLD followed by microtubule . . .
  

   

  

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