Targeting the unfolded protein response as a disease-modifying pathway in dementia

HIGHLIGHTS

  • who: Emad Sidhom and collaborators from the Department of Clinical Neurosciences, University of Cambridge, Cambridge , AH, UK have published the Article: Targeting the Unfolded Protein Response as a Disease-Modifying Pathway in Dementia, in the Journal: (JOURNAL) of 26/01/2022
  • what: The authors explore future directions for investigating the potential benefit of using trazodone or similar UPR-modulating compounds for disease modification in patients with Published: 11 February 2022 This review describes the cellular mechanisms and preclinical studies underpinning therapeutic approaches focusing on UPR modulation and describes evidence from epidemiology and early clinical trials . . .

     

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