Structural organization and zn2+-dependent subdomain interactions involving autoantigenic epitopes in the ring-b-box-coiled-coil (rbcc) region of ro52*

HIGHLIGHTS

• who: Janosch Hennig from the , terminal flanking residues, will be required to determine their specific contribution to folding and interactions in Ro By taking all experiments into account, the region between the RBCC Zn2⫹-binding motifs referred to as the RB linker seems to be of major importance for determining the overall fold, both of the RING-B-box region and for the entire RBCC region. It has a remarkable conservation, seems to be a stable entity in a protein context, and creates strong antigenic response in mice. The present results give improved molecular understanding of Ro . . .
  

   

  

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