Nmr spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus dna*

HIGHLIGHTS

• who: Christian Klein from the (UNIVERSITY) have published the Article: NMR Spectroscopy Reveals the Solution Dimerization Interface of p53 Core Domains Bound to Their Consensus DNA*, in the Journal: (JOURNAL) of October/17,/2001
• what: Initially, the NMR studies were intended to gain further insight into the mode of p53 regulation. To resolve the steric problems resulting from the attempt to combine the different symmetries of the four DBDs and the TD in a complex with a single DNA consensus site the authors propose that wild-type p53 tetramers might be capable of linking two . . .
  

   

  

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