Extensive trimming of short single-stranded dna oligonucleotides during replication-coupled gene editing in mammalian cells

HIGHLIGHTS

• who: Thomas W. van Ravesteyn and collaborators from the Division of Tumor Biology and Immunology, The Cancer Institute, CX Amsterdam, the have published the Article: Extensive trimming of short single-stranded DNA oligonucleotides during replication-coupled gene editing in mammalian cells, in the Journal: (JOURNAL) of October/29,/2020
• what: The authors propose a refined model for LMO-directed gene modification in mammalian cells that includes LMO degradation. Based on these data the authors propose a refinement of the current replication-dependent model for ssODN-directed gene modification in mammalian cells: LMOs are not incorporated . . .
  

   

  

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