The effects of nitroxyl (hno) on soluble guanylate cyclase activity

HIGHLIGHTS

• who: Thomas W. Miller from the (UNIVERSITY) have published the research work: The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity, in the Journal: (JOURNAL) of August/14,/2009
• what: The authors propose that HNO-mediated sGC activation can occur in one of at least three possible ways: 1) HNO could be converted to a very small amount of NO which activates sGC; 2) HNO could modify critical thiols on sGC to affect its activity; or 3) HNO could activate sGC via a direct interaction with the heme of sGC, akin to NO-mediated . . .
  

   

  

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