Allele-specific rna imaging shows that allelic imbalances can arise in tissues through transcriptional bursting

HIGHLIGHTS

  • who: Orsolya Symmons et al. from the Department of Bioengineering, University of Pennsylvania, Skirkanich Hall, Philadelphia, Pennsylvania have published the paper: Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting, in the Journal: (JOURNAL)
  • what: The authors demonstrate quantitative single molecule allele-specific RNA FISH adapted for use on tissue sections allowing the authors to determine the chromosome of origin of individual RNA molecules in formaldehyde-fixed tissues. Quantifying cell-to-cell heterogeneity in the chromosomal origin of RNA in tissue To determine how the chromosomal origin of RNAs . . .

     

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