The large hydrophilic loop of presenilin 1 is important for regulating γ-secretase complex assembly and dictating the amyloid β peptide (aβ) profile without affecting notch processing*

HIGHLIGHTS

• who: Johanna Wanngren from the (UNIVERSITY) have published the article: The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing*, in the Journal: (JOURNAL) of March/19,/2010
• how: To determine the topology for the PS1⌬exon 10 explore the altered A␤ generation observed in a knock-in molecule the authors introduced a glycosylation acceptor site (Asn-Sermouse model lacking a big portion of this loop .
• future: Future studies are warranted to explain the differential sensitivity of PS . . .
  

   

  

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