HIGHLIGHTS
- who: Anita Woods from the (UNIVERSITY) have published the research: RhoA/ROCK Signaling Regulates Sox9 Expression and Actin Organization during Chondrogenesis*, in the Journal: (JOURNAL) of August/10,/2004
- what: The authors show that pharmacological inhibition of ROCK signaling by Y27632 resulted in increased glycosaminoglycan synthesis and elevated expression of the chondrogenic transcription factor Sox9, whereas overexpression of RhoA in the chondrogenic cell line ATDC5 had the opposite effects. The authors show that the RhoA/ROCK pathway indeed fulfills these functions and plays an important role in coordinating actin organization, cell shape, and chondrogenic phenotype . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.