HIGHLIGHTS
- who: Tuan M. Tran from the LaboratoryIndiana University have published the article: Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria, in the Journal: Scientific Reports Scientific Reports
- what: Using pathways, upstream regulator and modular transcriptional analysis, the authors show that robust transcriptional changes during febrile malaria translated into striking quantitative and qualitative differences in the immunological response between naïve and malaria-experienced individuals, with naïve individuals having a dominant interferon-mediated, pro-inflammatory response likely driven by dendritic cells and monocytes as suggested by the modular transcriptional analysis . . .
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