Targeted disruption of the kcnj5 gene in the female mouse lowers aldosterone levels

HIGHLIGHTS

• who: Iris Hardege et al. from the Division have published the paper: Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels, in the Journal: (JOURNAL) of 16/01/2018
• what: The studies reported here show that female but not male Kcnj5-deficient mice have lowered plasma aldosterone levels compared with WT counterparts.
• how: Due to the lack of a commercially suitable antibody with specificity for the channel in the mouse (Supporting Data) the authors carried out Kcnj5 gene_expression analysis by qPCR of WT (+/+ ) mouse adrenal tissue. RNAseq reveals major . . .
  

   

  

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