Bridging of nucleosome-proximal dna double-strand breaks by parp2 enhances its interaction with hpf1

HIGHLIGHTS

• who: Guillaume Gaullier et al. from the Department of Biochemistry, of Colorado Boulder, Boulder, CO, United States of AmericaEditor: Robert WSobol, University of South have published the Article: Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1, in the Journal: PLOS ONE
• what: The authors demonstrate that the conformation of PARP2 bound to damaged chromatin provides a binding platform for the regulatory protein Histone PARylation Factor 1 (HPF1) and that the resulting HPF1•PARP2•nucleosome complex is enzymatically active. The authors show that PARP2 is capable of bridging DNA . . .
  

   

  

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