Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers

HIGHLIGHTS

  • who: Ryan Limbocker et al. from the Case Western Reserve University, United States have published the article: Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers, in the Journal: (JOURNAL)
  • what: As seminal agents in numerous protein misfolding diseases, the authors focused in this report on the misfolded oligomers formed by these proteins rather than on other conformers.
  • how: Statistics Data were analyzed using GraphPad Prism 8 (CA United_States) using an unpaired two-tailed Student's t-test or one-way ANOVA followed by . . .

     

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