HIGHLIGHTS
- who: Angelina Pavlic et al. from the Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, ER Maastricht, The Netherlands have published the Article: Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification, in the Journal: (JOURNAL)
- how: This review describes the current understanding of the role of VSMCs in VC and focuses on EV-biogenesis and nSMase2.
SUMMARY
Pharmacological inhibition of nSMase2 reduces the secretion of EVs by VSMCs and VSMC-driven calcification in_vitro, and diminishes atherogenesis in a mouse model of atherosclerosis . . .
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