HIGHLIGHTS
- who: Martin T. Johnson from the (UNIVERSITY) have published the research: The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma, in the Journal: (JOURNAL) of January/27,/2022
- what: The authors show using mitochondrial Ca2+-sensitive dyes that NCLX only partially contributes to mitochondrial Ca2+ extrusion in ASM cells. Through cellular imaging, RNA-Seq, and biochemical assays, the authors demonstrate that NCLX regulates these processes by preventing mitochondrial Ca2+ overload and supporting store-operated Ca2+ entry, activation of Ca2+/calmodulin-dependent kinase II, and transcriptional and metabolic . . .
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