HIGHLIGHTS
- who: The U and collaborators from the of Clinical Laboratory University of, Kyoto, Japan have published the paper: U2AF1S34F splicing alterations in myelodysplastic syndromes and Boultwood1 Bloodwise Molecular Haematology Unit Nuffield, in the Journal: (JOURNAL)
- what: The authors showed that U2AF1S34F induced skipping of exon 2 of the STRAP gene preferentially in erythroid colonies compared with granulomonocytic colonies . The authors demonstrated that expression of U2AF1S34F in human hematopoietic progenitors results in impaired erythroid differentiation as a result of poor hemoglobinization and reduced growth of erythroid progenitors. The study demonstrates a link between U2AF1S34F and skewed . . .
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