HIGHLIGHTS
- who: Kanut Laoharawee and colleagues from the Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA have published the article: A Pan-RNase Inhibitor Enabling CRISPR-mRNA Platforms for Engineering of Primary Human Monocytes, in the Journal: (JOURNAL) of 30/07/2022
- what: The authors demonstrate that CRISPR-Cas9 RNPs can be used for efficient gene knockout in primary human The authors demonstrate that intracellular RNases are likely responsible for poor and heterogenous mRNA expression as incorporation of allows efficient genome engineering following mRNA-based delivery of Cas9 and base editor enzymes. The authors demonstrate . . .
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