Histone deacetylase inhibitors correct the cholesterol storage defect in most niemann-pick c1 mutant cells

HIGHLIGHTS

• who: Nina H. Pipalia from the Department have published the article: Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells, in the Journal: (JOURNAL) of 22/09/2016
• what: The WT construct used in this study has four variants as compared with a standard reference NPC1 sequence .
• how: Similar results were obtained with panobinostat and NPC1-25 was also only partially responsive to panobinostat as compared with the other cell lines tested (Fig 4B).
• future: The cells were expanded and stock cultures were frozen for . . .
  

   

  

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