Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the p2y

HIGHLIGHTS

• who: Stefan Milde from the (UNIVERSITY) have published the paper: Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y, in the Journal: (JOURNAL)
• what: The work described here seeks to determine whether the inflammatory neuronal loss induced by peripheral LPS can be prevented by blocking the microglial ­P2Y6 receptor.

SUMMARY

To help elucidate mechanisms in_vitro, the authors co-cultured BV-2 microglia with differentiated PC12 dopaminergic neurons, and found that LPS induced microglial phagocytosis of neurons, which was prevented by a specific . . .

 



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