The fnip co-chaperones decelerate the hsp90 chaperone cycle and enhance drug binding

HIGHLIGHTS

• who: Mark R. Woodford from the Department of Urology, SUNY Upstate Medical University, East Adams Street, Syracuse, New York, Cancer Research Institute, SUNY have published the paper: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 29/06/2016
• what: The authors show that the tumour suppressor FLCN is an Hsp90 client protein and its binding partners FNIP1/FNIP2 function as co-chaperones. The authors demonstrate by MS analysis that FLCN interacts with the molecular chaperones Hsp70 and Hsp90, as well as members . . .
  

   

  

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