HIGHLIGHTS
- who: Xinmiao Zhang from the DepartmentUniversity Hospital Groningen, Groningen, The Netherlands have published the paper: Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells, in the Journal: Scientific Reports Scientific Reports
- what: In keeping with this and because emerging evidence suggest a role for p53 in the development of metabolic d iseases23,24, this study was conducted to further substantiate the initial findings on MGO mediated p53 activation and to assess the consequences hereof on downstream pathways such as mTORC1. The study was approved by local ethics committee (Medizinische Ethik-kommission . . .
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