HIGHLIGHTS
- who: Jaeyong Cho and collaborators from the Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan have published the research: UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader, in the Journal: (JOURNAL)
- what: The authors previously reported that glucokinase is ubiquitinated and degraded by cereblon with an unknown endogenous glucokinase Here the authors show that is a glucokinase
- how: These in_vitro data indicated that glucose might behave as a glucokinase-binding antagonist for ubiquitination and degradation by cereblon and glucokinaseE256K -mutated protein was resistant to ubiquitination similar to arginine . . .
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