A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation*

HIGHLIGHTS

• who: Maximilian L. Würstle from the example, HeLa cervical cancer cells express ⬃12-fold higher amounts of Apaf, than procaspase, (41), indicating that the likelihood of two procaspase, molecules to bind side-by-side on the apoptosome is very lowNevertheless, caspase, activation and apoptosis execution is highly efficient in these cells. Similar unfavorable ratios for a dimerization-based activation process were reported in various other cell lines, including , breast cancer cells, human colon carcinoma cell lines (HCT-116, Lovo, DLD-1, HT29), and panels of , glioblastoma and , melanoma cell lines (39, , ). Structural analysis based on electron . . .
  

   

  

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