The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation*

HIGHLIGHTS

• who: C. Randell Brown from the CRandell Brown, Allison B. Wolfe, Dongying Cui, and Hui-Ling Chiang, From the Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania , The gluconeogenic enzyme fructose-1, bisphosphatase (FBPase) is degraded in the vacuole when glucose is added to glucose-starved cells. Before it is delivered to the vacuole, however, FBPase is imported into intermediate carriers called Vid (vacuole import and degradation) vesicles. Here, using biochemical and genetic approaches, we identified a requirement for , in FBPase degradation. , encodes the ⑀-COP subunit of COPI (coat protein complex . . .
  

   

  

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