HIGHLIGHTS
- who: Philipp Metzger from the Munich, Germany Institute of Innate Immunity, University of Bonn, Venusberg-Campus , have published the Article: Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer, in the Journal: (JOURNAL)
- what: The authors provide evidence that the treatment with immunostimulatory RNA reprograms the TME of by reducing the suppressive activity of MDSC polarizing myeloid cells into a M1-like state and recruiting DC. The authors provide novel insights into the dual role of signaling in MDSC's suppressive function and provide evidence that host-intrinsic signaling may . . .
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