Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane lrp1*

HIGHLIGHTS

• who: Jo V. Rushworth from the Jo VRushworth, Heledd H. Griffiths, Nicole T. Watt, and Nigel M. Hooper, From the School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, JT, United Kingdom Background: Prion protein (PrPC) is a receptor for amyloid-␤ oligomers (A␤Os). Results: A␤O binding to PrPC and cytotoxicity require transmembrane , and are reduced by cholesterol depletion and A␤O remodeling. Conclusions: Cellular binding and toxicity of A␤Os are dependent on PrPC being localized in a raft-based complex. Significance: Remodeling A . . .
  

   

  

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