Hdac inhibitor saha normalizes the levels of vlcfas in human skin fibroblasts from x-ald patients and downregulates the expression of proinflammatory cytokines in abcd1/2-silenced mouse astrocytes

HIGHLIGHTS

• who: Jaspreet Singh from the DepartmentMedical University have published the research: HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes, in the Journal: (JOURNAL) of 30/05/2011
• what: This study shows that treatment with the potent and selective HDAC inhibitor SAHA normalized the levels of VLCFA in skin fibroblasts from XALD patients by increasing the peroxisomal ␤-oxidation activity. Because SAHA crosses the blood-brain barrier (BBB), increases acetylation in brain , and reduces neuroinflammation, the . . .
  

   

  

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