Structure of the dicer-2-r2d2 heterodimer bound to a small rna duplex

HIGHLIGHTS

• who: Sonomi Yamaguchi from the (UNIVERSITY) have published the research: Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex, in the Journal: (JOURNAL) of 11/Oct/2021
• what: The authors report cryo-electron microscopy structures of the Dicer-2- R2D2 and Dicer-2-R2D2-siRNA complexes. The authors solved the high-resolution cryo-electron microscopy (cryo-EM) structure of the Dicer-2-R2D2-siRNA complex, and provide mechanistic insights into dsRNA cleavage and siRNA loading by the Dicer-2-R2D2 heterodimer. On the basis of the present structure, along with previous . . .
  

   

  

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