The pax6b homeodomain is dispensable for pancreatic endocrine cell differentiation in zebrafish*

HIGHLIGHTS

• who: Vincianne Verbruggen from the mice, thereby contributing to the abnormal glucose metabolism (12)This example indicates that a, % reduction of Pax, levels is sufficient to perturb expression of some pancreatic target genes. However, our observation of the increase of ␣ cells after partial knockdown of pax6b is quite peculiar because this effect is not occurring after full knockdown of pax6b. A similar phenomenon has recently been shown for the pancreatic transcription factor Ptf1a. Indeed, a partial reduction of Ptf1a levels in zebrafish embryos strongly promotes endocrine cell fate, whereas such an effect is not observed when Ptf1a . . .
  

   

  

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