Type iv p-type atpases distinguish mono- versus diacyl phosphatidylserine using a cytofacial exit gate in the membrane domain*

HIGHLIGHTS

• who: Ryan D. Baldridge from the Ryan DBaldridge1, Peng Xu, and Todd R. Graham, From the Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee , Background: Type IV, type ATPases (P4-ATPases) Drs, and Dnf, are known to recognize different phospholipid headgroups. Results: Dnf, preferentially recognizes lysophospholipid, but mutations in transmembrane (TM) segments, and , allow recognition of diacyl phosphatidylserine. Conclusions: Residues within TM1, cooperate with the proline ⫹ , residue in , to define, ATPase specificity. Significance: We provide insight into how a, type ATPase subgroup evolved a new substrate. Type IV, type ATPases (P4-ATPases) use the energy from ATP . . .
  

   

  

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