Crystal structure of nalp3 protein pyrin domain (pyd) and its implications in inflammasome assembly*

HIGHLIGHTS

• who: Ju Young Bae from the Ju Young Bae and Hyun Ho Park, From the School of Biotechnology, Graduate School of Biochemistry, and Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, South Korea , inflammasome, composed of the three proteins NALP3, ASC, and Caspase-1, is a macromolecular complex responsible for the innate immune response against infection with bacterial and viral pathogensFormation of the inflammasome can lead to the activation of inflammatory caspases, such as Caspase-1, which then activate pro-inflammatory cytokines by proteolytic cleavage. The assembly of the , inflammasome depends on the protein-interacting domain known . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.