Molecular basis for increased risk for late-onset alzheimer disease due to the naturally occurring l28p mutation in apolipoprotein e4*

HIGHLIGHTS

• who: Letta Argyri from the (UNIVERSITY) have published the paper: Molecular Basis for Increased Risk for Late-onset Alzheimer Disease Due to the Naturally Occurring L28P Mutation in Apolipoprotein E4*, in the Journal: (JOURNAL) of November/25,/2013
• what: The authors propose that these structural and functional changes underlie the observed added risk for AD development in carriers of apoE4[L28P]. The analysis showed that lipoprotein particle-associated apoE4[L28P] was capable to induce ROS formation inside SKN-SH cells to a much higher degree than WT apoE4 (Fig 11D). The authors show here that . . .
  

   

  

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