HIGHLIGHTS
- who: James E. Metherall from the (UNIVERSITY) have published the paper: Role of Multidrug Resistance P-glycoproteins in Cholesterol Biosynthesis (*), in the Journal: (JOURNAL) of August/23,/1995
- what: 271, 2627-2633), the authors demonstrate that progesterone inhibits cholesterol biosynthesis, causing the accumulation of a number of cholesterol precursors. The authors show that a steroid hormone's ability to inhibit cholesterol biosynthesis is correlated with: 1) its general hydrophobicity and 2) its ability to inhibit MDR activity. The authors propose a model in which MDR is required for transport of sterols from the plasma_membrane to . . .
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