Regulation of the o-linked β-n-acetylglucosamine transferase by insulin signaling*

HIGHLIGHTS

• who: Stephen A. Whelan from the Stephen AWhelan1, M. Daniel Lane, and Gerald W. Hart, From the Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, Linked ␤-N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of, linked ␤-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to stimuli or stress analogous to phosphorylation by Ser/Thr-kinases. Like protein phosphatases, OGT appears to be targeted to myriad specific substrates by transiently interacting with specific targeting subunits. Here, we show that OGT is activated by insulin signaling. Insulin treatment of , adipocytes . . .
  

   

  

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