HIGHLIGHTS
- who: Cristian Turato from the Deptof Medicine, University of have published the paper: SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity, in the Journal: Scientific Reports Scientific Reports
- what: This study has been designed to investigate and characterize the interplay and functional modulation of Myc by SerpinB3 in human liver cancer. The authors provide for the first time evidence indicating that Myc expression is significantly and mechanistically up-regulated by SerpinB3 through calpain and Hippo-dependent molecular mechanisms in human liver cancer cells and in a transgenic mice model. The authors employed HCC specimens, obtained . . .
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