The n-terminal arm of the helicobacter pylori ni2+-dependent transcription factor nikr is required for specific dna binding*

HIGHLIGHTS

• who: Erin L. Benanti from the Erin LBenanti and Peter T. Chivers, From the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri , The Ni2ⴙ-dependent transcription factor NikR is widespread among microbes. The two experimentally characterized NikR orthologs, from Helicobacter pylori and Escherichia coli, display vastly different regulatory capabilities in response to increased intracellular Ni2ⴙ. Here, we demonstrate that the nine-residue, terminal arm present in H. pylori NikR plays a critical role in the expanded regulatory capabilities of this NikR family member. Specifically, the, terminal arm is required to inhibit . . .
  

   

  

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