Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes*210

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• who: Soazig Le Lay from the (UNIVERSITY) have published the Article: Cholesterol, a Cell Size-dependent Signal That Regulates Glucose Metabolism and Gene Expression in Adipocytes*210, in the Journal: (JOURNAL) of February/14,/2001
• what: The authors show here that sterol regulatory element-binding protein 2 (SREBP-2) and its target genes are induced in the adipose_tissue of several models of rodent obesity, suggesting cholesterol imbalance in enlarged adipocytes. The authors show that treatment with methyl␤-cyclodextrin, which mimics the membrane cholesterol reduction of hypertrophied adipocytes, induces insulin resistance. The aim of this work . . .
  

   

  

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