Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, mrp1*

HIGHLIGHTS

• who: Koji Koike from the (UNIVERSITY) have published the research work: Multiple Membrane-associated Tryptophan Residues Contribute to the Transport Activity and Substrate Specificity of the Human Multidrug Resistance Protein, MRP1*, in the Journal: (JOURNAL) of July/10,/2002

SUMMARY

MRP1 (gene symbol ABCC1) was originally cloned from a multidrug-resistant small cell lung cancer cell line, and its expression has been detected in many human tumor cell lines that were either drug-selected or inherently resistant to a wide range of chemotherapeutic agents. Xenobiotic metabolites that are MRP1 substrates include the folic . . .

 



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