Loss of timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin ii*

HIGHLIGHTS

• who: Ratnadeep Basu from the EXPERIMENTAL PROCEDURES Experimental Animals and Procedures-Wild type (WT) mice were purchased from The Jackson LaboratoryWe crossbred Timp3⫺/⫺ (19) and Mmp2⫺/⫺ (20) mice to generate Timp3⫺/⫺/Mmp2⫺/⫺ mice. Timp3⫺/⫺/Mmp2⫺/⫺ mice are healthy and fertile. All mice are in a C BL/, background. Alzet micro-osmotic pumps (Model, Durect Corp.) were implanted subcutaneously in male mice of the indicated genotypes to deliver, ., mg/kg/day Ang II (21-23) or saline (control). Broad spectrum MMP inhibitor (MMPi have published the Article: Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in . . .
  

   

  

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