Determinants of gata-1 binding to dna

HIGHLIGHTS

• who: Rodolfo Ghirlando from the (UNIVERSITY) have published the paper: Determinants of GATA-1 Binding to DNA, in the Journal: (JOURNAL) of June/17,/2003
• what: The authors show that the specificity for AGATAA over AGATCT arises from the C-terminal non-finger basic domain. The authors show that replacement of the C-terminal arms of the N-terminal zinc_fingers of GATA-1 and -2 with the corresponding C-terminal arm of the C-terminal finger of GATA-1 results in affinities and specificities similar to those noted for the native C-terminal finger. In . . .
  

   

  

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