Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with egfr tki and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells

HIGHLIGHTS

  • who: Sissel E. Dyrstad and collaborators from the Department of Pathology, Haukeland University Hospital, Bergen, Norway, Université Paris-Saclay, Villejuif, France have published the article: Blocking Aerobic Glycolysis by Targeting Pyruvate Dehydrogenase Kinase in Combination with EGFR TKI and Ionizing Radiation Increases Therapeutic Effect in Non-Small Cell Lung Cancer Cells, in the Journal: (JOURNAL)
  • what: The authors propose that inhibition of glycolysis will add to the therapeutic effects and possibly prevent development of resistance against both TKIs and in NSCLC. The authors investigate metabolic rewiring in acquired drug resistance in epidermal growth factor receptor . . .

     

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