Successive phosphorylation of p27kip1 protein at serine-10 and c terminus crucially controls its potency to inactivate cdk2*

HIGHLIGHTS

• who: Atish R. Mohanty from the (UNIVERSITY) have published the paper: Successive Phosphorylation of p27KIP1 Protein at Serine-10 and C Terminus Crucially Controls Its Potency to Inactivate Cdk2*, in the Journal: (JOURNAL) of June/22,/2012
• how: To further confirm the double dependence of activation of p27-bound Cdk2 on Cdc6 and C-terminal phosphorylation of the bound p27 the authors carried out anchorage deprivation-and-replate analysis.

SUMMARY

Phosphorylation at Ser-10 and Thr-197 occurs early in growth-stimulated cells and facilitates its own stabilization and nuclear exclusion . . .

 



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